5TH SEM MEDICINAL CHEMISTRY ASSIGNMENT-6

5TH SEM MEDICINAL CHEMISTRY

ASSIGNMENT-6

Prepared by: Ms. Mitali H. Jasani

A.    DRUG ACTING ON ANS

Ø  Write Neurochemistry of Acetylcholine.05

Ø  What are Parasympathomimetic Agents? Classify them with examples.06

Ø  Define and classify cholinergic agents. Explain the SAR of Parasympathomimetics. 06

Ø  Write a note on Parasympatholytic agents.05

Ø  Give classification of Parasympatholytics with suitable examples.06

Ø  Give SAR of Muscarinic Antagonists.           05

Ø  Give SAR of cholineesters (Parasympathomimetics).05

Ø  Write note on Neuromuscular blocking agents.05 III

Ø  Write a note on Ganglionic blockers.05

Ø  What are Sympathomimetic Agents? Classify them with examples.             06

Ø  Give classification of Sympathomimetics with suitable examples.06

Ø  Write SAR of Beta-Phenylethanolamine class of Sympathomimetic agents.05

Ø  Give SAR of Beta-blockers.06

Ø  Write note on sympatholytic agents 05

Ø  Give IUPAC name and synthesis of Dicyclomine HCl and Atenolol.05

Ø  Give the synthesis and use of Propranolol and Atenolol.06

Ø  Write synthesis of Salbutamol and Atenolol.             05

5TH SEM MEDICINAL CHEMISTRY ASSIGNMENT-5

5TH SEM MEDICINAL CHEMISTRY

ASSIGNMENT-5

Prepared by: Ms. Mitali H. Jasani

A.    DRUG ACTING ON G.I.T.  TRACT

Ø  Write a short note on following: Antispasmodics. 04

Ø  Explain Irritable Bowel Syndrome. Give the details of drugs used in the treatment of it.05

Ø  Write synthesis of Promethazine and Ranitidine.05

Ø  Write synthesis of Diatrizoic acid and Omeprazole.05

Ø  Give synthesis of Ranitidine and Omeprazole.05

Ø  What is peptic ulcer? Give brief note on H2-antagonists.05 II

Ø  Write a short note on Protom pump inhibitors.05 II

Ø    What are proton pumps Inhibitors? Explain its mechanism of action. Give   Synthesis of Omeprazole 06

Ø  Write IUPAC name and synthesis of Omeprazole and Ranitidine.05

Ø  Write a note on Prokinetics and laxatives.05

Ø  Write a note on antidiarrheals 05

Ø  What are antiemetic agents? Classify them with examples 05

5TH SEM MEDICINAL CHEMISTRY ASSIGNMENT-4

5TH SEM MEDICINAL CHEMISTRY

ASSIGNMENT-4

Prepared by: Ms. Mitali H. Jasani

    DRUG ACTING ON RESPIRATORY TRACT

Ø  Write a short note on following: Expectorants

Ø  What is Asthma? Explain Anti-asthmatic drugs in detail.06 

Ø  Write a note on Mucolytics and Decongestants.05

Ø  Write a short note on Expectoranats and Antitussives.05

Ø  Write a note on Antitussive agents. 05

5TH SEM MEDICINAL CHEMISTRY ASSIGNMENT-3

5TH SEM MEDICINAL CHEMISTRY

ASSIGNMENT-3

Prepared by: Ms. Mitali H. Jasani

HISTORY OF MEDICINAL CHEMISTRY

1. Write a note on development of Medicinal Chemistry.05
2. What is Medicinal Chemistry? Give importance of Medicinal chemistry in drug discovery.05
3. What is Medicinal Chemistry? Give importance of Medicinal chemist in drug development.06

PHYSICO-CHEMICAL PROPERTIES

1. Write a short note on following:  Bioisosterism 04
2. What are Isomers? Draw the structure of one drug each having Optical isomerism and Geometrical isomerism.05
3. What is eudismic ratio? Give importance of Chirality in drug action. 05
4. Write a note on geometric & optical isomerism.05
5. Explain the physicochemical parameters affecting drug absorption. 06
6. What are Physiological properties? Explain Partition coefficient and Protein binding in detail.05
7. Explain the effect of following parameter on biological activity.05
8.  1). Complexation  2). Hydrogen bonding
9. Enumerate the physicochemical properties affecting biological activity. Explain Hydrogen bonding properties in detail. 06
10. Define Bioisosterism. How they are useful in designing new drug.06
11. Write a note on Partition coefficient and Ionization that affect biological activity.06
12. Write a short note on Bioisosterism.05
13. How Isomerism affect the biological activity.06

5TH SEM MEDICINAL CHEMISTRY ASSIGNMENT-2

5TH SEM MEDICINAL CHEMISTRY

ASSIGNMENT-2

Prepared by: Ms. Mitali H. Jasani

DIAGNOSTIC AGENTS

1. Write a short note on following :1)Radiological Contrast Media 04 
2. Write synthesis of Diatrizoic acid 
3.  What are diagnostic agents? Write a note on radiopharmaceuticals.05 
4. Write a note on Diagnostic agents.06 
5.  Give a note on radiological contrast media. Give synthesis of diatriazoic acid. 05

5TH SEM MEDICINAL CHEMISTRY ASSIGNMENT-1

5TH SEM MEDICINAL CHEMISTRY

ASSIGNMENT-1

Prepared by: Ms. Mitali H. Jasani

AUTOCOIDS

1. Enlist various histaminic receptors. Discuss neurochemistry of histamine.06
2. Write a short note on following :1)Eicosanoids,2) H1-Antagonists 08
3. Discuss SAR of antihistamines.06 II
4. Write a short note on H2-receptor antagonist05
5. Give SAR of H2-Antagonists.05
6. Discuss the chemistry of prostaglandins 05
7. What are Eicosanoids ? Write in brief about Eicosanoid biosynthesis.05
8. What are Eicosanoids? Give name of major biosynthesis pathways and drug actions mediated by Eicosanoids. 06
9. Explain eicosanoids approved for human clinical use.05 II
10. Outline synthesis of Diphenhydramine and Chlorcyclizine.05
11. Outline synthesis and uses of Diphenoxylate and Cetrizine.05
12. Write synthesis of Cetrizine and Ephedrine.05
13. Write IUPAC name and synthesis of Cyproheptadine and Chlorpheniramine.05