5TH SEM MEDICINAL CHEMISTRY ASSIGNMENT-1

5TH SEM MEDICINAL CHEMISTRY

ASSIGNMENT-1

Prepared by: Ms. Mitali H. Jasani

AUTOCOIDS

1. Enlist various histaminic receptors. Discuss neurochemistry of histamine.06
2. Write a short note on following :1)Eicosanoids,2) H1-Antagonists 08
3. Discuss SAR of antihistamines.06 II
4. Write a short note on H2-receptor antagonist05
5. Give SAR of H2-Antagonists.05
6. Discuss the chemistry of prostaglandins 05
7. What are Eicosanoids ? Write in brief about Eicosanoid biosynthesis.05
8. What are Eicosanoids? Give name of major biosynthesis pathways and drug actions mediated by Eicosanoids. 06
9. Explain eicosanoids approved for human clinical use.05 II
10. Outline synthesis of Diphenhydramine and Chlorcyclizine.05
11. Outline synthesis and uses of Diphenoxylate and Cetrizine.05
12. Write synthesis of Cetrizine and Ephedrine.05
13. Write IUPAC name and synthesis of Cyproheptadine and Chlorpheniramine.05